MIA2 — MIA SH3 domain ER export factor 2

MIA2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

MIA2's module in each cell type

Cell type	Module	Shares the module with
Enterocytes	Enterocyte fatty-acid catabolism Lipid metabolism	ACOX1, ACSL5, CYP3A5, GDA, MUC3A, OGDH, RIOK3	View in SCUBA
Gamma-delta T cells	Interferon Antiviral Response Inflammation	ANKRD44, DDX17, DDX60L, IARS2, KIAA0319L, KRBOX5, LZIC, PIK3CD +14 more
Macrophages	Transcriptional Regulation Housekeeping	AATF, ABHD5, ARID3B, DCP1A, GGNBP2, MSI2, NR2C2, NSMAF +18 more	View in SCUBA
Mucosal-associated invariant T cell	Chromatin Remodeling DNA/chromatin regulation	BAZ2B, C1RL, CD2AP, GIT2, KIF5B, RIF1, SPAG9, SUPT16H +1 more

About the gene

Synonyms	cTAGE-5A, cTAGE-5B, cTAGE-5C, cTAGE-5D, CTAGE5, FLJ22404, MEA6, MGEA, MGEA11, MGEA6, TALI
Chromosome	14: 39230231-39388513
Predicted location	Intracellular, Membrane
Essential gene	No
Protein class	Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Function

Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum. Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.