NR2C2 — Nuclear receptor subfamily 2 group C member 2
NR2C2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NR2C2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | RNA Surveillance/NMD RNA processing & translation | AFG3L2, ANKRD13A, ARPP19, BRD10, C5orf24, DNM1L, ERVK3-1, KCTD20 +8 more | |
| Macrophages | Transcriptional Regulation Housekeeping | AATF, ABHD5, ARID3B, DCP1A, GGNBP2, MIA2, MSI2, NSMAF +18 more | View in SCUBA |
About the gene
| Synonyms | hTAK1, TAK1, TR2R1, TR4 |
|---|---|
| Chromosome | 3: 14947583-15053600 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Nuclear receptors, Plasma proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding, Receptor, Repressor |
| Biological process | Differentiation, Spermatogenesis, Transcription, Transcription regulation |
Function
Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.