DDR1 — Discoidin domain receptor tyrosine kinase 1
DDR1 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DDR1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Lipid Metabolism Nutrient processing | ABCD1, ACOT11, ACSS2, ADAP1, AP1B1, ATP1A1, CACFD1, CAPN5 +29 more | View in SCUBA |
About the gene
| Synonyms | CAK, CD167, EDDR1, NEP, NTRK4, PTK3A, RTK6 |
|---|---|
| Chromosome | 6: 30876421-30900156 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, Enzymes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Kinase, Receptor, Transferase, Tyrosine-protein kinase |
| Biological process | Lactation, Pregnancy |
Function
Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.