Lipid Metabolism
Gene co-expression module in Colonocytes
| Category | Nutrient metabolism |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 38 genes have a known function matching the annotation |
Why this annotation
Top hub genes are strongly enriched for lipid metabolism: DGAT1 (diacylglycerol acyltransferase, triglyceride synthesis), LYPLA2 (lysophospholipase), ACSS2 (acetyl-CoA synthetase for lipid synthesis), MBOAT7 (lysophospholipid acyltransferase), SLC25A1 (mitochondrial citrate transporter feeding lipogenesis), GPT (amino acid-lipid metabolism interface), GGT6 (glutathione/lipid metabolism). MYO1A is a brush border myosin supporting absorptive function. EPN1 links endocytosis to lipid handling. No strong inflammation association. Uniform expression consistent with a housekeeping lipid metabolic program in colonocytes.
Genes
Most correlated modules
- Colonocyte Cytoskeletal Contractility · correlation 0.87
- Colonocyte Detoxification · correlation 0.87
- Lysosomal Lipid Stress · correlation 0.87
- Membrane Cytoskeletal Remodeling · correlation 0.84
- Lipid Xenobiotic Metabolism · correlation 0.81
- Mature Colonocyte Identity · correlation 0.77
- Glycosylation & Membrane · correlation 0.75
- Colonocyte Senescence · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.