AP1B1 — Adaptor related protein complex 1 subunit beta 1
AP1B1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AP1B1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | DNA Damage Response DNA/chromatin regulation | CCAR1, CHD8, DOCK2, EP400, ERBIN, GOLM2, IPO8, LRBA +17 more | |
| Macrophages | Endosomal Membrane Trafficking Vesicular traficking | A2M, ARHGAP4, ARHGEF6, ATG4C, B3GNT7, CRTAP, ETV5, FYB1 +20 more | View in SCUBA |
About the gene
| Synonyms | ADTB1, AP105A, BAM22, CLAPB2 |
|---|---|
| Chromosome | 22: 29327680-29388583 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters |
| Biological process | Protein transport, Transport |
Function
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.