ADAP1 — ArfGAP with dual PH domains 1
ADAP1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADAP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytotoxic effector Cytotoxicity | ALOX5AP, AOAH, CD244, CMIP, CPNE7, CRTAM, DAPK2, DOCK5 +15 more | View in SCUBA |
| Gamma-delta T cells | Naive T cell quiescence T cell maturation | ARL4C, BCL9L, BMAL1, CALM1, CAMK1D, CD44, CD5, CD6 +10 more |
About the gene
| Synonyms | CENTA1, GCS1L |
|---|---|
| Chromosome | 7: 897900-955407 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | GTPase activation |
Function
GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Regulates the incorporation of CD63 and CD9 into multivesicular bodies.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.