DDX10 — DEAD-box helicase 10
DDX10 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DDX10's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | DNA Repair Housekeeping Housekeeping | ACBD6, CD320, DUS1L, EEF1D, EIF3G, FAAP20, FARSA, GADD45GIP1 +15 more | View in SCUBA |
About the gene
| Synonyms | Dbp4, HRH-J8 |
|---|---|
| Chromosome | 11: 108665058-108940999 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Enzymes, Essential proteins, Predicted intracellular proteins |
| Molecular function | Helicase, Hydrolase, RNA-binding |
Function
Putative ATP-dependent RNA helicase that plays various role in innate immunity or inflammation. Plays a role in the enhancement of AIM2-induced inflammasome activation by interacting with AIM2 and stabilizing its protein level. Negatively regulates viral infection by promoting interferon beta production and interferon stimulated genes/ISGs expression
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.