CD320 — CD320 molecule
CD320 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD320's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Caveolae-mediated Transcytosis Metabolite transfer | ADIPOR2, CAV1, CAV2, CCDC85A, EEPD1, EMP2, ENAH, HIF3A +19 more | View in SCUBA |
| Gamma-delta T cells | Tissue-resident gd T Tissue residence | AKR1C3, ASCL2, BFSP1, CARNS1, CES1, CMKLR1, CTBP2, CXCR1 +21 more | |
| Innate lymphoid cells | Glycolysis & OxPhos Metabolism | ANXA7, ARF3, ATP5MC3, CD74, CNBP, COX6A1, COX6B1, IL2RG +10 more | View in SCUBA |
| Lymphatic endothelial | Oxidative Stress Protection Stress | ALDH2, ANAPC16, BCL7C, CAVIN2, CCL21, CRACR2B, FXYD6, GUSB +10 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cytotoxic Effector cytotoxicity | ANXA4, CCM2, CST7, DYNLRB1, GZMM, LIMD2, MCUB, MGMT +10 more | |
| Pericytes | Vascular Pericyte Identity Developmental | ABCG1, ACVRL1, ATP11A, CASP10, CCM2L, GPRC5B, KL, MPZL2 +7 more | View in SCUBA |
About the gene
| Synonyms | 8D6, 8D6A, TCblR |
|---|---|
| Chromosome | 19: 8302127-8308358 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, Disease related genes, Human disease related genes, Predicted membrane proteins |
| Molecular function | Growth factor |
Function
Receptor for transcobalamin saturated with cobalamin (TCbl). Plays an important role in cobalamin uptake. Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells. Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation. Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.