DNA Repair Housekeeping
Gene co-expression module in Colonocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 15 of 24 genes have a known function matching the annotation |
Why this annotation
This module contains a mixture of programs: mitochondrial import (TOMM40, TIMM44), DNA repair (POLD2, PAXX, FAAP20, PRPF19), tRNA/rRNA processing (DUS1L, PDCD11, SURF6, DDX10, FARSA), and translation (EIF3G, EEF1D). GADD45GIP1 (PCNA-interacting stress response) and PFDN6 (prefoldin chaperone) are top hubs. The module is moderately coherent with core membership throughout. In the context of neighboring ribosome biogenesis (M53) and mitochondrial (M103) modules, this appears to represent a broader housekeeping/genome maintenance program active in crypt colonocytes. The DNA replication and repair genes (POLD2, PAXX, FAAP20, PRPF19) are notable. Given the mix, the dominant theme across hub genes is general housekeeping/DNA maintenance.
Genes
Most correlated modules
- Mitochondrial Biogenesis · correlation 0.96
- Ribosome Biogenesis · correlation 0.94
- SWI-SNF DNA Repair · correlation 0.94
- Mitochondrial Translation · correlation 0.93
- Chaperone Proteostasis · correlation 0.91
- SUMOylation Chromatin · correlation 0.91
- snRNP Splicing · correlation 0.90
- Pre-mRNA Splicing · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.