EIF3G — Eukaryotic translation initiation factor 3 subunit G
EIF3G belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EIF3G's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Translation machinery Housekeeping | ATP5PO, BTF3, COX4I1, EEF2, EIF3D, EIF3K, MZT2B, RACK1 +2 more | View in SCUBA |
| Fibroblasts | Ribosome Biogenesis Housekeeping | BTF3, EEF1B2, EIF3K, RPL36AL, RPL4, RPS10, SLC25A6, SNRPD2 +1 more | View in SCUBA |
| Macrophages | Low-Coherence Mixed Technical artifact | AAMP, ALKBH7, CDC123, COMMD5, DNTTIP1, EIF4E2, FAM32A, ITGAE +8 more | View in SCUBA |
| Mucosal-associated invariant T cell | Leukocyte Housekeeping Housekeeping | AP2S1, APRT, ATP5MC2, CCDC85B, ERP29, GABARAPL2, GMFG, HCST +5 more | |
| Natural Killer cells | ILC1/NK Cytotoxic Cytotoxicity | A1BG, CASK, CLDND1, GZMK, ITM2C, KLRB1, NCF1, PDCD4 +4 more | View in SCUBA |
About the gene
| Synonyms | eIF3-delta, eIF3-p44, EIF3S4 |
|---|---|
| Chromosome | 19: 10115014-10119918 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Initiation factor, RNA-binding |
| Biological process | Protein biosynthesis |
Function
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem- loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA. . (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.