DEFA5 — Defensin alpha 5
DEFA5 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DEFA5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Antimicrobial Oxidative Defense Antibacterial | ADAMDEC1, ALDOA, APOL3, CALHM6, CLEC10A, COX16, CPVL, DEFA6 +30 more | View in SCUBA |
About the gene
| Synonyms | DEF5, HD-5 |
|---|---|
| Chromosome | 8: 7055304-7056739 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted secreted proteins |
| Molecular function | Antibiotic, Antimicrobial, Defensin, Fungicide |
| Biological process | Immunity, Innate immunity |
Function
Host-defense peptide that maintains sterility in the urogenital system. Has antimicrobial activity against a wide range of bacteria, including Gram-negative E.coli, P.aeruginosa and S.typhimurium, and Gram-positive E.aerogenes, S.aureus, B.cereus, E.faecium and L.monocytogenes. Confers resistance to intestinal infection by S.typhimurium. Exhibits antimicrobial activity against enteric commensal bacteria such as B.adolescentis, L.acidophilus, B.breve, L.fermentum, B.longum and S.thermophilus. Binds to bacterial membranes and causes membrane disintegration. Induces the secretion of the chemokine IL-8 by intestinal epithelial cells. Binds to B.antracis lef/lethal factor, a major virulence factor from B.anthracis, and neutralizes its enzymatic activity. (Microbial infection) Acts as a target for S.flexneri infection by binding to the bacterium, possibly via bacterial surface proteins, and thereby augmenting infectivity via enhanced bacterial adhesion and invasion of epithelial cells and tissues
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.