Antimicrobial Oxidative Defense
Gene co-expression module in Macrophages
| Category | Antibacterial |
|---|---|
| Genes | 39 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 39 genes have a known function matching the annotation |
Why this annotation
GPX1 (glutathione peroxidase 1, antioxidant defense, res_mac 5x), DNASE1L3 (DNase involved in apoptotic cell clearance and NET degradation, res_mac 5.7x), DEFA5 (alpha-defensin, antimicrobial peptide, res_mac 5.2x), NCF4 (NADPH oxidase component, reactive oxygen species production), SERPINF1 (PEDF, anti-angiogenic/neuroprotective), QPRT (NAD biosynthesis from tryptophan), ALDOA (glycolysis). The strong res_mac enrichment of key genes and the combination of antimicrobial (DEFA5), oxidative defense (GPX1), and apoptotic clearance (DNASE1L3) genes suggest a resident macrophage antimicrobial/oxidative defense program.
Genes
ADAMDEC1, ALDOA, APOL3, CALHM6, CLEC10A, COX16, CPVL, DEFA5, DEFA6, DNAJC4, DNASE1L3, EBI3, EIF4A1, FCGRT, FUCA1, GATD3, GPX1, IFITM2, IFITM3, IGLL5, ITM2C, JAML, JCHAIN, LAG3, LBHD1, MKKS, MMP25, NCF4, PDLIM2, PLAAT3, PLAAT4, POLD4, QPRT, RNASET2, SELENOP, SERPINF1, TMIGD3, U2AF1, VAMP5
Most correlated modules
- Resident Mac Niche · correlation 0.77
- MHC-II Antigen Presentation · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.