CALHM6 — Calcium homeostasis modulator family member 6
CALHM6 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CALHM6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | IFN-γ MHC-II Response Inflammatory | CD74, CXCL11, CXCL9, GBP4, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DRA +3 more | View in SCUBA |
| Macrophages | Antimicrobial Oxidative Defense Antibacterial | ADAMDEC1, ALDOA, APOL3, CLEC10A, COX16, CPVL, DEFA5, DEFA6 +30 more | View in SCUBA |
About the gene
| Synonyms | C6orf187, dJ93H18.5, FAM26F, INAM, OTTHUMP00000017061, OTTHUMP00000017062, RP1-93H18.5 |
|---|---|
| Chromosome | 6: 116461370-116463771 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Ion channel |
| Biological process | Ion transport, Transport |
Function
Pore-forming subunit of an ATP-permeable channel (By similarity). In response to pathogen-derived and proinflammatory stimuli, relocates from intracellular compartments to NK-dendritic cell and NK-macrophage immune synapses where it mediates ATP efflux and NK cell activation involved in antimicrobial and antitumor responses (By similarity). May assemble to form gap junction channel-like structures with gating and ion conductance likely regulated by membrane lipids and voltage rather than by extracellular calcium levels
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.