APOL3 — Apolipoprotein L3
APOL3 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
APOL3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | mRNA Splicing Processing RNA processing | ANXA2R, BTN3A1, CCNL1, CHCHD7, CMPK1, DDX5, EIF4A2, EIF5 +7 more | View in SCUBA |
| Endothelial | Arterial EC Homeostasis Endothelial cell development | BMX, EXOC6, FAXDC2, FTH1, GABARAPL1, GAS6, GIMAP1, GIMAP4 +10 more | View in SCUBA |
| Innate lymphoid cells | Mitochondrial Metabolism Mitochondrial & OxPhos | ACTR10, ANP32A, ATP6V1E1, ECHS1, ERCC1, ETFB, GLRX3, HIGD1A +12 more | View in SCUBA |
| Macrophages | Antimicrobial Oxidative Defense Antibacterial | ADAMDEC1, ALDOA, CALHM6, CLEC10A, COX16, CPVL, DEFA5, DEFA6 +30 more | View in SCUBA |
| Monocytes | IFN-γ Monocyte Response Inflammatory | ANKRD22, ATF5, CXCL9, HAPLN3, IL2RA, IL2RG, LYSMD2, NFE2L3 +2 more | View in SCUBA |
| Mucosal-associated invariant T cell | ER Stress Response Protein processing & ER | ACADVL, GYG1, HLA-F, HSP90B1, LENG8, MAP4K1, PIM1, PLEKHF1 +4 more |
About the gene
| Synonyms | APOLIII, CG12-1 |
|---|---|
| Chromosome | 22: 36140329-36166177 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Lipid transport, Transport |
Function
May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.