DESI1 — Desumoylating isopeptidase 1
DESI1 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DESI1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Inflammasome Activation Inflammation | ACBD3, ANKRD22, BFAR, CA8, CARD16, CASP1, CHRM3, CRELD2 +17 more | View in SCUBA |
About the gene
| Synonyms | D15Wsu75e, DESI-1, FAM152B, POST, PPPDE2 |
|---|---|
| Chromosome | 22: 41598028-41621043 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Hydrolase, Protease |
Function
Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity (By similarity). Desumoylates ZBTB46 (By similarity). Collaborates with UBQLN4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm. Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity towards synthetic substrates 4- methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside and S- depalmitoylation probe 5 (DPP-5).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.