CHRM3 — Cholinergic receptor muscarinic 3
CHRM3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CHRM3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Crypt antimicrobial progenitor Antibacterial | CAMK1D, DIAPH2, EMP2, HES1, IFITM2, LYZ, PTPN13, SULF2 | View in SCUBA |
| Hematopoietic progenitor cells | HSC Quiescence Program Stemness | ADGRG6, AVP, CCDC175, CD164, CDH7, EGLN3, HEMGN, HLF +7 more |
About the gene
| Chromosome | 1: 239386565-239915452 |
|---|---|
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.