ACBD3 — Acyl-CoA binding domain containing 3
ACBD3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ACBD3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | DNA Damage Ubiquitin DNA/chromatin regulation | CDADC1, CTPS1, CWC25, FNIP1, ING3, KLHL18, RALGAPA1, RCOR1 +7 more | |
| Macrophages | RNA Processing Regulation Housekeeping | AQR, ARCN1, BFAR, BNIP3L, CCNI, CCNK, DIS3, DNAJC3 +15 more | View in SCUBA |
About the gene
| Synonyms | GCP60, GOCAP1, GOLPH1, PAP7 |
|---|---|
| Chromosome | 1: 226144679-226186741 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Transporters |
| Biological process | Host-virus interaction, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis |
Function
Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi. Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase. (Microbial infection) Plays an essential role in Aichi virus RNA replication by recruiting PI4KB at the viral replication sites.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.