CRELD2 — Cysteine rich with EGF like domains 2
CRELD2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CRELD2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | ER stress UPR Protein processing & ER | CCT2, CDK2AP2, DDX39A, DNAJB11, DSTN, EIF5A, GPSM3, GTF3A +9 more | View in SCUBA |
| Endothelial | Hypoxia Response Stress | C1orf122, CSTB, EFHD2, FKBP1A, HIF1A, LAPTM4B, NECTIN2, RAB13 +3 more | View in SCUBA |
| Gamma-delta T cells | T Cell Exhaustion Exhaustion | ACADVL, ACSS1, ADSS2, B4GALT3, CDK11A, CHP1, CNOT2, CNOT8 +20 more | |
| Goblet cells | UPR Chaperone Response Stress | CALR, GMPPB, LRRC59, MANF, NUCB2, P4HB, PDIA3, PDIA4 +2 more | View in SCUBA |
| Macrophages | ER Protein Glycosylation Vesicular traficking | AK2, ALG3, ALG5, BABAM1, CKLF, DDOST, DPM3, FAM136A +21 more | View in SCUBA |
About the gene
| Synonyms | MGC11256 |
|---|---|
| Chromosome | 22: 49918167-49927540 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Isomerase |
Function
Protein disulfide isomerase (By similarity). Might play a role in the unfolded protein response (By similarity). May regulate transport of alpha4-beta2 neuronal acetylcholine receptor.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.