Inflammasome Activation
Gene co-expression module in Colonocytes
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 26 genes have a known function matching the annotation |
Why this annotation
Top hub genes CASP1 (inflammasome caspase), PSMB8 (immunoproteasome beta subunit), PSME1/PSME2 (PA28 immunoproteasome activators), CARD16 (CARD domain/caspase recruitment), NMI (N-myc interactor, IFN-induced), IFITM2 (interferon-induced transmembrane), and CRELD2 (ER stress/UPR marker) define an inflammasome and immunoproteasome activation program. Significantly upregulated in UC inflammation (delta_inflammation_UC=0.865, sig.). CRELD2 links this module to the ER stress neighborhood (M26, M15). The combination of CASP1, CARD16, and immunoproteasome components is characteristic of epithelial inflammasome activation during colitis.
Genes
Most correlated modules
- Unfolded Protein Response · correlation 0.83
- ER-Golgi Trafficking · correlation 0.82
- Secretory Differentiation · correlation 0.81
- Inflammatory Stress Response · correlation 0.80
- ER-Golgi Trafficking · correlation 0.79
- Chromatin Regulatory Response · correlation 0.79
- Inflammatory Regenerative State · correlation 0.79
- Actin Cytoskeletal Regulation · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.