DESI2 — Desumoylating isopeptidase 2
DESI2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DESI2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Protein/ER secretory machinery Protein processing & ER | ACTR2, ATP5IF1, ATP5ME, BAZ1B, CMC2, CNPY2, COMMD3, COPZ1 +16 more | View in SCUBA |
| Macrophages | Microtubule Organization Cytoskeletal | CAMSAP2, FAF2, HERPUD2, KCMF1, LSM14A, MAPK6, NRDC, PAFAH1B1 +14 more | View in SCUBA |
About the gene
| Synonyms | C1orf121, CGI-146, DESI-2, FAM152A, FLJ21998, PNAS-4, PPPDE1 |
|---|---|
| Chromosome | 1: 244653103-244709033 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protease |
| Biological process | Ubl conjugation pathway |
Function
Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'- linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization. Exhibits palmitoyl protein thioesterase (S- depalmitoylation) activity towards synthetic substrates 4- methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside and S- depalmitoylation probe 5 (DPP-5)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.