LSM14A — LSM14A mRNA processing body assembly factor
LSM14A belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LSM14A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | mRNA splicing RNA processing | ANAPC5, C11orf58, C1orf43, DDX46, DNAJC7, HSPA4, LUC7L3, MRPL47 +8 more | View in SCUBA |
| Gamma-delta T cells | Translation & Proteostasis RNA processing & translation | ARAP2, ATG13, BRPF1, CLINT1, CRKL, E2F3, EEF2, EIF2AK2 +15 more | |
| Macrophages | Microtubule Organization Cytoskeletal | CAMSAP2, DESI2, FAF2, HERPUD2, KCMF1, MAPK6, NRDC, PAFAH1B1 +14 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Transcriptional Identity T cell maturation | AAK1, ANKRD36B, ATG16L2, BCL11B, EMB, ETS1, GOLGA8B, HNRNPUL2 +8 more |
About the gene
| Synonyms | C19orf13, DKFZP434D1335, FAM61A, RAP55, RAP55A |
|---|---|
| Chromosome | 19: 34172504-34229288 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Developmental protein, Repressor, Ribonucleoprotein |
| Biological process | Translation regulation |
Function
Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation. Acts as a repressor of mRNA translation. May play a role in mitotic spindle assembly.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.