PAFAH1B1 — Platelet activating factor acetylhydrolase 1b regulatory subunit 1
PAFAH1B1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PAFAH1B1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Chromatin regulation DNA/chromatin regulation | ANKRD11, BIRC6, CNTRL, EP300, FAM118A, GOLGA4, IRF2, KAT6A +12 more | View in SCUBA |
| Endothelial | Actin Cytoskeletal Remodeling Cytoskeletal | ACTR2, ANKRD11, ARPC4, CAP1, EIF4G1, FYTTD1, G3BP1, GSPT1 +8 more | View in SCUBA |
| Gamma-delta T cells | Wnt-STAT3 Signaling TCR Signaling | BTBD1, COPA, CTNNB1, DHX9, EZR, HECTD1, NUP153, SPRTN +5 more | |
| Lymphatic endothelial | ZEB1-driven EMT endothelial development | ASH1L, CUX1, ERBIN, ITSN2, KIF1B, MKLN1, NFAT5, NIPBL +7 more | View in SCUBA |
| Macrophages | Microtubule Organization Cytoskeletal | CAMSAP2, DESI2, FAF2, HERPUD2, KCMF1, LSM14A, MAPK6, NRDC +14 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cellular Maintenance Housekeeping | DCTN4, FAM13B, GBF1, GOLGA4, GPRIN3, HUWE1, ITSN2, PPP6R3 +4 more | |
| Smooth muscle cells | Actin Cytoskeletal Scaffold Cytoskeletal | ACTN4, ATP2B4, ATRX, DDX5, DLGAP4, EIF4G2, FAT1, GNAI2 +13 more | View in SCUBA |
About the gene
| Synonyms | LIS1, MDCR, MDS, NudF, PAFAH |
|---|---|
| Chromosome | 17: 2593210-2685615 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Developmental protein |
| Biological process | Cell cycle, Cell division, Differentiation, Lipid degradation, Lipid metabolism, Mitosis, Neurogenesis, Transport |
Function
Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition- dependent manner (By similarity). Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos. May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.