Microtubule Organization
Gene co-expression module in Macrophages
| Category | Cytoskeletal |
|---|---|
| Genes | 23 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 23 genes have a known function matching the annotation |
Why this annotation
Hub genes include PAFAH1B1 (LIS1, dynein-associated microtubule regulator), CAMSAP2 (microtubule minus-end stabilization), SLK (Ste20-like kinase, cytoskeletal regulation), RAB8B (vesicle trafficking), alongside mRNA processing genes LSM14A (P-body component), SRSF4 (splicing factor), XRN1 (5'-3' exoribonuclease, mRNA decay), ZFR (RNA binding). TICAM1 (TRIF) adds innate immune signaling. The module is weakly coherent and combines microtubule/cytoskeletal and mRNA decay programs, but microtubule regulators dominate the top PageRank positions. Neighbor context (M117 vesicular, M9 RAB-rich) supports cytoskeletal-trafficking theme.
Genes
CAMSAP2, DESI2, FAF2, HERPUD2, KCMF1, LSM14A, MAPK6, NRDC, PAFAH1B1, PPFIA1, PPP2R2A, PPP2R3C, RAB8B, RNF13, SLK, SRSF4, STK40, TBC1D23, TICAM1, UBE2K, UBR4, XRN1, ZFR
Most correlated modules
- Transcriptional Regulation · correlation 0.96
- NF-κB AP-1 Signaling · correlation 0.96
- RAB-mediated Trafficking · correlation 0.96
- Endolysosomal Trafficking · correlation 0.96
- Monocyte Lipid Metabolism · correlation 0.95
- Transcriptional Repression · correlation 0.95
- RNA Processing Housekeeping · correlation 0.95
- Ubiquitin-Proteasome Regulation · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.