MAPK6 — Mitogen-activated protein kinase 6
MAPK6 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MAPK6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Membrane Trafficking Protein processing & ER | B4GALT1, BTF3L4, CELF1, CLTC, CSNK1G3, CTBS, DERL2, DYNC1LI2 +23 more | View in SCUBA |
| Enterocytes | Brush-border enterocyte Absorption | CD2AP, CEACAM20, ERBIN, GK, HHLA2, MAN1A1, NCKAP5, SLC36A1 | View in SCUBA |
| Lymphatic endothelial | DNA Damage Apoptosis DNA/chromatin regulation | AZIN1, BAZ1A, HNRNPC, IVNS1ABP, OTUD4, PHLDB2, SPEN, STX3 +4 more | View in SCUBA |
| Macrophages | Microtubule Organization Cytoskeletal | CAMSAP2, DESI2, FAF2, HERPUD2, KCMF1, LSM14A, NRDC, PAFAH1B1 +14 more | View in SCUBA |
About the gene
| Synonyms | ERK3, HsT17250, p97MAPK, PRKM6 |
|---|---|
| Chromosome | 15: 51952106-52067375 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
| Biological process | Cell cycle |
Function
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.