DLAT — Dihydrolipoamide S-acetyltransferase
DLAT belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DLAT's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Mitochondrial Biogenesis Mitochondrial & OxPhos | ACOT7, AGL, AKAP1, ARHGAP18, COQ9, CS, CSRP1, DCAF6 +20 more | View in SCUBA |
About the gene
| Synonyms | DLTA, E2, PDC-E2 |
|---|---|
| Chromosome | 11: 112025408-112064404 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Citric acid cycle related proteins, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Acyltransferase, Transferase |
| Biological process | Carbohydrate metabolism, Glucose metabolism, Tricarboxylic acid cycle |
Function
As part of the pyruvate dehydrogenase complex, catalyzes the transfers of an acetyl group to a lipoic acid moiety (Probable). The pyruvate dehydrogenase complex, catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle (Probable)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.