ACOT7 — Acyl-CoA thioesterase 7
ACOT7 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ACOT7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Cellular Housekeeping Housekeeping | ACAT2, CISD2, FDPS, NUDT21, PA2G4, PPIA, PSMC3, PSMG2 +9 more | View in SCUBA |
| Endothelial | ER Calcium Stress Stress | ATP2A2, CALU, ELOVL5, GTF2A2, LYAR, PSMD7, RCC2, UFD1 +1 more | View in SCUBA |
| Gamma-delta T cells | Basal Lipid Metabolism Housekeeping | ADCY3, AHCY, CLN6, DENND6B, FANCL, MGLL, MPST, NUDT8 +6 more | |
| Smooth muscle cells | Microtubule biogenesis Cytoskeletal | FBXL22, ILF2, LIMS2, NUCB2, PGRMC1, PHGDH, PPP2R1A, TBCB +3 more | View in SCUBA |
About the gene
| Synonyms | ACH1, ACT, BACH, CTE-II, hBACH, LACH1, MGC1126 |
|---|---|
| Chromosome | 1: 6264269-6393767 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Serine esterase |
| Biological process | Fatty acid metabolism, Lipid metabolism |
Function
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain- lengths of C8-C18. May play an important physiological function in brain
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.