ARHGAP18 — Rho GTPase activating protein 18
ARHGAP18 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARHGAP18's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Rho-GTPase Migration migration & adhesion | ARHGEF7, FNBP1, HELZ, LPXN, MAP4K1, MIS18BP1, PREX1, RORA +4 more | View in SCUBA |
| Endothelial | CXCL12 Angiogenic Chemotaxis Chemotaxis | ACKR3, AFAP1L1, ARHGEF7, CHST1, CXCR4, FHL3, FSCN1, GABRE +15 more | View in SCUBA |
| Fibroblasts | Caveolae Mechanosensing Cytoskeletal | APLP2, BDKRB2, CACNA1H, CAV1, CAV2, CD9, CPED1, DMD +10 more | View in SCUBA |
| Lymphatic endothelial | Lymphangiogenesis ECM endothelial development | CEP68, CFI, DIPK2B, EGFL7, ELK3, ELN, FLT4, KCNN3 +10 more | View in SCUBA |
| Macrophages | Myeloid Innate Signaling Innate immunity | ADCY7, BMP2K, C3AR1, C6orf62, CD46, CD84, CLTC, CNEP1R1 +34 more | View in SCUBA |
| Monocytes | M2 Macrophage Polarization Tissue homeostasis | ABCC5, ADAP2, CD84, FRMD4B, GNPDA1, LIPA, MAF, MRC1 | View in SCUBA |
| Pericytes | Cytoskeletal Remodeling Cytoskeletal | F2RL3, FSCN1, IVNS1ABP, JUP, PASK, SEMA3F, TBCD, VWA1 | View in SCUBA |
About the gene
| Synonyms | bA307O14.2, MacGAP |
|---|---|
| Chromosome | 6: 129576132-129710177 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | GTPase activation |
Function
Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1. Regulates cell shape, spreading, and migration
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.