Mitochondrial Biogenesis
Gene co-expression module in Colonocytes
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 29 genes have a known function matching the annotation |
Why this annotation
Hub genes CS (citrate synthase), IDH1 (isocitrate dehydrogenase), DLAT (pyruvate dehydrogenase E2), PPARGC1B (PGC-1beta, master mitochondrial biogenesis coactivator), NDUFS1 (Complex I), COQ9 (coenzyme Q biosynthesis), IMMT (mitofilin/inner mitochondrial membrane), FASTK (mitochondrial RNA stability), ENDOG (mitochondrial endonuclease) all point to mitochondrial biogenesis and TCA cycle. AGL (glycogen debranching) and GALM (galactose mutarotase) add carbohydrate catabolism. DDAH1 (ADMA dimethylarginine dimethylaminohydrolase) links to NO metabolism. PPARGC1B as a top hub gene anchors this as a mitochondrial biogenesis module. Neighbor to M99 and M141 (pure OxPhos), supporting the mitochondrial metabolic neighborhood. Downregulated in inflammation, consistent with colonocyte metabolic suppression during IBD.
Genes
Most correlated modules
- Mitochondrial Membrane Dynamics · correlation 0.92
- Colonocyte HOX Identity · correlation 0.91
- Oxidative Phosphorylation · correlation 0.90
- Colonocyte Differentiation · correlation 0.89
- Crypt Colonocyte Identity · correlation 0.89
- Mitochondrial Peroxisomal Metabolism · correlation 0.89
- Oxidative Phosphorylation · correlation 0.85
- Spliceosome Assembly · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.