DNAJC13 — DnaJ heat shock protein family (Hsp40) member C13
DNAJC13 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DNAJC13's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Myeloid Receptor Signaling Innate immunity | ADGRE5, ANKFY1, ANKIB1, ATP1B1, CPT1A, DOCK7, EPS15, GALNT1 +29 more | View in SCUBA |
| Neutrophils | Endocytic Vesicular Trafficking Vesicular traficking | CLINT1, LNPK, PHACTR2, PRAM1, PRKAA1, PTPN22, SEC63, VCL |
About the gene
| Synonyms | KIAA0678, RME8 |
|---|---|
| Chromosome | 3: 132417502-132539032 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted membrane proteins |
| Molecular function | Chaperone |
| Biological process | Protein transport, Transport |
Function
Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR. Involved in the regulation of endosomal membrane tubulation and regulates the dynamics of SNX1 on the endosomal membrane; via association with WASHC2 may link the WASH complex to the retromer SNX-BAR subcomplex.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.