GALNT1 — Polypeptide N-acetylgalactosaminyltransferase 1

GALNT1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

GALNT1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Lysosomal proteases Protein processing & ER	CD63, CD82, CNPY3, CTSA, CTSC, CTSD, CTSZ, FUT8 +2 more	View in SCUBA
CD4⁺ T cells	Actomyosin signaling migration & adhesion	ACIN1, CYBC1, EIF4G3, HNRNPA3, NCKAP1L, PPP1R12A, PRKCH, PTPRA +8 more	View in SCUBA
CD8⁺ T cells	TCR Proximal Signaling TCR Signaling	ACTN4, CD3G, CMIP, IVNS1ABP, LCP2, MSN, PTPN22, PTPRA +3 more	View in SCUBA
Endothelial	Endothelial Cell Migration migration & adhesion	CISD1, CTHRC1, MARCKS, MARCKSL1, NARF, PHLDB2, RHOJ, SHC1 +5 more	View in SCUBA
Gamma-delta T cells	Transcriptional Coactivation DNA/chromatin regulation	ATN1, ATP13A3, ATP1A1, CREBBP, FAM76B, GAK, MDM2, PDS5A +12 more
Lymphatic endothelial	Endothelial Identity endothelial development	CHST12, ENDOD1, EPHB4, F2R, F8, KDR, NR2F2, PECAM1 +4 more	View in SCUBA
Macrophages	Myeloid Receptor Signaling Innate immunity	ADGRE5, ANKFY1, ANKIB1, ATP1B1, CPT1A, DNAJC13, DOCK7, EPS15 +29 more	View in SCUBA

About the gene

Synonyms	GalNAc-T1
Chromosome	18: 35581117-35711834
Predicted location	Intracellular, Membrane
Essential gene	No
Protein class	Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Molecular function	Glycosyltransferase, Transferase

Function

Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates such as apomucin-, MUC5AC-, MUC1- and MUC2-derived peptides

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.