SCUBA

ADGRE5 — Adhesion G protein-coupled receptor E5

ADGRE5 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ADGRE5's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsTNF/NF-kB response
BCR/AP1/NFKb pathway
ATF3, BHLHE40, CHD1, CMTM6, CYLD, DUSP5, FMNL1, IRF2BP2 +7 moreView in SCUBA
CD4⁺ T cellsNF-kB Feedback Response
TCR/AP1/NFKb pathway
ARL5B, ATF3, CSRNP1, NFKBIZ, PPP1R15B, RASGEF1B, TIPARP, TNFAIP3 +2 moreView in SCUBA
CD8⁺ T cellsActomyosin Motility
Cytoskeletal
ACTR2, AP2B1, ARGLU1, CAPNS1, EMB, GNAI2, MYH9, PPP1R12A +2 moreView in SCUBA
Gamma-delta T cellsTGF-beta Response
Immune regulation
CD83, CHMP1B, CHST7, DDIT3, DNAAF2, EHD4, FAM43A, ID1 +15 more
Goblet cellsHypoxia Metabolic Stress
Stress
ANKRD37, ARL4A, FBXO32, IRS2, KLF2, LRRFIP1, SKIL, TENT5AView in SCUBA
Innate lymphoid cellsNK ILC Tissue Homing
Homing & TEM
AKAP13, AREG, ARL4C, ATP1B3, B3GNT7, BTG1, CCDC107, CCR6 +25 moreView in SCUBA
MacrophagesMyeloid Receptor Signaling
Innate immunity
ANKFY1, ANKIB1, ATP1B1, CPT1A, DNAJC13, DOCK7, EPS15, GALNT1 +29 moreView in SCUBA
Mucosal-associated invariant T cellNF-κB Effector Activation
Inflammation
BCL2A1, CCL20, CCL3, CCL3L3, CCL4, CCL4L2, DUSP10, EGR2 +10 more
Natural Killer cellsNF-κB Activation
Inflammation
BCL3, BHLHE40, CSRNP1, DUSP10, NFKB1, NFKB2, NINJ1, OTULIN +3 moreView in SCUBA

About the gene

SynonymsCD97, TM7LN1
Chromosome19: 14380501-14408725
Predicted locationIntracellular, Membrane, Secreted
Essential geneNo
Protein classCD markers, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters
Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processCell adhesion

Function

Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.