Myeloid Receptor Signaling
Gene co-expression module in Macrophages
| Category | Innate immunity |
|---|---|
| Genes | 38 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 38 genes have a known function matching the annotation |
Why this annotation
SYK is a central non-receptor tyrosine kinase in myeloid cell signaling downstream of Fc receptors, integrins, and pattern recognition receptors. PIK3R1 (p85α) is the regulatory subunit of PI3K, a key downstream effector of SYK. PREX1 and DOCK7 are Rac/Cdc42 GEFs activated downstream of PI3K. MAP3K1 is a MAPK kinase kinase linking receptor signals to JNK/ERK. SH2B3 (LNK) negatively regulates cytokine and growth factor receptor signaling. TGFBR2 adds a TGF-β receptor signaling component. Together these genes suggest a myeloid receptor-proximal signaling module. Weak coherence and uniform expression indicate this is a loosely co-regulated program rather than a tightly activated state.
Genes
ADGRE5, ANKFY1, ANKIB1, ATP1B1, CPT1A, DNAJC13, DOCK7, EPS15, GALNT1, GALNT10, IL6ST, KLF7, MAN2A1, MAP3K1, MTMR10, NIN, PALS1, PIK3R1, PLEKHA2, PPP2R5E, PREX1, PRKAR2A, SGPP1, SH2B3, SPIN1, ST8SIA4, SYK, TBC1D9, TGFBR2, TOP2B, TTC3, UBL3, USP48, USP9X, VOPP1, WBP1L, XPO6, ZFHX3
Most correlated modules
- Post-transcriptional Regulation · correlation 0.96
- Chromatin Remodeling · correlation 0.96
- Sphingolipid Membrane Homeostasis · correlation 0.96
- Chromatin Regulatory Genes · correlation 0.95
- DNA Damage Repair · correlation 0.94
- RNA Processing Transport · correlation 0.93
- TGF-beta Signaling · correlation 0.92
- Myeloid Differentiation Identity · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.