DTX1 — Deltex E3 ubiquitin ligase 1
DTX1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DTX1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Germinal Center Maturation B cell maturation | BCAS4, BCL7A, CCDC69, DCK, ITGAE, LSM10, NEIL1, POU2AF1 +5 more | View in SCUBA |
| CD4⁺ T cells | Proliferation/differentiation Cell cycle | AIG1, AKAP7, CCND1, KLF4, SUSD4, TLR5, ZNF827 | View in SCUBA |
About the gene
| Synonyms | hDx-1, RNF140 |
|---|---|
| Chromosome | 12: 113056730-113098028 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Notch signaling pathway |
Function
Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell- fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.