CD19⁺ B cells: gene co-expression modules
Antigen-specific lymphocytes bearing surface immunoglobulin; after germinal-centre selection they class-switch, mutate their receptors, and mature into memory cells or antibody-secreting plasma cells.
SCUBA's reference network for CD19⁺ B cells holds 97 gene modules covering 1,387 genes. Each module is a group of genes that rise and fall together across these cells, annotated with the biological process it most likely represents.
View the CD19⁺ B cells network in SCUBA
Anti-viral (5)
- Antiviral Restriction · 10 genes
- Immunoproteasome IFN · 9 genes
- Interferon Response · 16 genes
- MHC-I Antigen Presentation · 10 genes
- Type I Interferon · 18 genes
B cell maturation (24)
- Activated B cell · 15 genes
- Atypical memory B cell · 14 genes
- B cell activation · 13 genes
- B cell activation signaling · 18 genes
- B cell identity · 9 genes
- B Cell Identity Signaling · 8 genes
- B cell identity TFs · 9 genes
- B-cell activation · 24 genes
- B-cell activation signaling · 9 genes
- B-cell antigen presentation · 15 genes
- B-cell Maturation · 12 genes
- B-cell signaling regulators · 12 genes
- BCR signaling/maturation · 18 genes
- Dark-zone GC B-cell · 11 genes
- Germinal center B-cell · 16 genes
- Germinal Center Maturation · 14 genes
- IgA plasma cell · 11 genes
- MHC-II antigen presentation · 18 genes
- MHC-II antigen presentation · 20 genes
- Naive B cell · 24 genes
- Naive B-cell identity · 16 genes
- Plasma cell secretory · 18 genes
- Somatic Hypermutation · 12 genes
- Tissue-resident memory B · 13 genes
BCR/AP1/NFKb pathway (14)
- Activation/Migration · 20 genes
- AP-1 Immediate Early · 16 genes
- B cell activation · 16 genes
- B cell quiescence · 9 genes
- B-cell signaling regulators · 12 genes
- BCR Ras signaling · 21 genes
- BCR Signaling Regulation · 14 genes
- Immediate Early NFkB · 12 genes
- Immediate early response · 16 genes
- Lymphoid signaling regulators · 13 genes
- NF-kB activation/survival · 18 genes
- NF-kB signaling · 14 genes
- NFkB/MAPK activation · 16 genes
- TNF/NF-kB response · 16 genes
Cell cycle (10)
- Cell Cycle G1/S · 17 genes
- Cell Cycle Proliferation · 13 genes
- DNA Replication · 11 genes
- DNA Replication · 13 genes
- DNA Replication · 12 genes
- G1/S Replication · 12 genes
- G2/M Mitosis · 16 genes
- Mitotic Spindle · 12 genes
- Mitotic Spindle · 12 genes
- Replication Licensing · 14 genes
Cytoskeletal (4)
- Actin Cytoskeleton · 23 genes
- Actin Cytoskeleton · 17 genes
- Actin Cytoskeleton · 10 genes
- Actin cytoskeleton remodeling · 18 genes
DNA/chromatin regulation (6)
- Chromatin & genome maintenance · 17 genes
- Chromatin Modification · 15 genes
- Chromatin modifiers · 10 genes
- Chromatin Regulation · 12 genes
- Chromatin Regulation · 17 genes
- Chromatin Remodeling · 18 genes
Intercellular communication (2)
- Notch signaling · 11 genes
- TGF-beta/differentiation · 9 genes
migration & adhesion (4)
- Adhesion/Migration · 20 genes
- Cytoskeleton/motility · 20 genes
- Leukocyte Migration Signaling · 14 genes
- Membrane adhesion remodeling · 15 genes
Mitochondrial & OxPhos (10)
- Glycolysis Biosynthesis · 13 genes
- Glycolysis OxPhos · 10 genes
- Mitochondrial Redox · 10 genes
- Mitochondrial Translation · 11 genes
- Nucleotide Metabolism Biosynthesis · 22 genes
- Oxidative Phosphorylation · 15 genes
- Oxidative Phosphorylation · 17 genes
- Oxidative Phosphorylation · 9 genes
- Oxidative Phosphorylation · 16 genes
- Oxidative Phosphorylation · 11 genes
Protein processing & ER (4)
- Chaperonin Protein Folding · 14 genes
- ER/vesicle trafficking · 10 genes
- Lysosomal proteases · 11 genes
- Proteasome Complex · 12 genes
RNA processing (6)
- mRNA Splicing · 16 genes
- mRNA Splicing · 10 genes
- mRNA splicing · 10 genes
- mRNA splicing factors · 21 genes
- RNA Processing · 23 genes
- Spliceosome snRNP · 13 genes
Stress (8)
- ATF4 Stress Response · 12 genes
- Early Response Stress · 9 genes
- Heat shock chaperones · 10 genes
- Heat Shock Response · 22 genes
- Hypoxia/metabolic stress · 11 genes
- Immediate early response · 18 genes
- Integrated Stress Response · 13 genes
- Oxidative/ER stress · 15 genes