SCUBA

ITGAE — Integrin subunit alpha E

ITGAE belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ITGAE's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsGerminal Center Maturation
B cell maturation
BCAS4, BCL7A, CCDC69, DCK, DTX1, LSM10, NEIL1, POU2AF1 +5 moreView in SCUBA
CD4⁺ T cellsIntegrin Adhesion Migration
migration & adhesion
ARAP2, ATF7IP, C4orf3, CLEC2B, COTL1, CTSH, DEK, DIAPH1 +11 moreView in SCUBA
CD8⁺ T cellsGut Residence Trm
Gut residence
CD96, FUT8, METTL8, MYO7A, NAB1, NAP1L4, PAG1, RAB27A +4 moreView in SCUBA
EndothelialNF-κB Oxidative Stress
Stress
ACP1, ALDH7A1, ARHGDIB, CCDC85C, CDC25B, CDKN3, CMSS1, COPRS +13 moreView in SCUBA
Gamma-delta T cellsTissue Resident CD103+
Tissue residence
ADRB1, BCAS4, BLMH, CCNJL, CD160, CD96, CLIC5, CLNK +28 more
Hematopoietic progenitor cellsHematopoietic Progenitor Identity
Stemness
CD38, DAD1, HSH2D, HYAL3, KIT, MBOAT2, MTHFD2, PARVB +2 more
MacrophagesLow-Coherence Mixed
Technical artifact
AAMP, ALKBH7, CDC123, COMMD5, DNTTIP1, EIF3G, EIF4E2, FAM32A +8 moreView in SCUBA
Mucosal-associated invariant T cellTissue Residency
Tissue residence
ACSL1, AMFR, CRACDL, DHX36, HES4, IRF8, LZTFL1, MACO1 +8 more
Natural Killer cellsTissue-Resident NK
Gut residency
ADRB1, CAMK4, GPR34, GPR55, LRRC25, MYO1E, NCR2, S100A13 +2 moreView in SCUBA

About the gene

SynonymsCD103, HUMINAE
Chromosome17: 3714628-3801188
Predicted locationIntracellular, Membrane
Essential geneNo
Protein classCD markers, Predicted intracellular proteins, Predicted membrane proteins
Molecular functionIntegrin, Receptor
Biological processCell adhesion

Function

Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.