POU2AF1 — POU class 2 homeobox associating factor 1
POU2AF1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
POU2AF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Germinal Center Maturation B cell maturation | BCAS4, BCL7A, CCDC69, DCK, DTX1, ITGAE, LSM10, NEIL1 +5 more | View in SCUBA |
| CD4⁺ T cells | Tfh CXCL13 program B cell help | ASCL2, C11orf96, CD8B2, CXCL13, CXXC5, FILIP1L, FZD3, GFOD1 +5 more | View in SCUBA |
About the gene
| Synonyms | BOB1, OBF1, OCA-B |
|---|---|
| Chromosome | 11: 111352255-111455630 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Activator |
| Biological process | Transcription, Transcription regulation |
Function
Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2. It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2. It recognizes the POU domains of POU2F1/OCT1 and POU2F2/OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers. Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.