EPHA7 — EPH receptor A7

EPHA7 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

EPHA7's module in each cell type

Cell type	Module	Shares the module with
Fibroblasts	Subepithelial Fibroblast Developmental	A2M, ABCA10, ABCA6, ABCA8, ABCA9, ADAMDEC1, CFD, CTSC +8 more	View in SCUBA

About the gene

Synonyms	Hek11
Chromosome	6: 93240020-93419687
Predicted location	Intracellular, Membrane
Essential gene	No
Protein class	Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Molecular function	Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
Biological process	Apoptosis, Neurogenesis

Function

Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 and MAPK3 which are phosphorylated upon activation of EPHA7

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.