CFD — Complement factor D
CFD belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CFD's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Subepithelial Fibroblast Developmental | A2M, ABCA10, ABCA6, ABCA8, ABCA9, ADAMDEC1, CTSC, EDIL3 +8 more | View in SCUBA |
| Hematopoietic progenitor cells | Promyelocyte Granule Genes Granulocyte development | AZU1, CEBPD, CTSG, ELANE, MPO, PLPPR3, PRTN3, RNASE2 +1 more | |
| Macrophages | Resident Mac Identity Tissue homeostasis | ACVRL1, CCND1, CD200R1, CR1, CTSF, EMB, EPHX1, F13A1 +16 more | View in SCUBA |
| Pericytes | Stromal ECM Production ECM production | ABCA8, CCL11, CTSK, DCN, FBLN1, LUM, MFAP4, VCAN | View in SCUBA |
| Smooth muscle cells | Synthetic Matrix Phenotype ECM remodeling | APOE, GAS6, GJA1, MAP1LC3A, MXRA5, PHF14, PLAU, POSTN +1 more | View in SCUBA |
About the gene
| Synonyms | ADN, DF, PFD |
|---|---|
| Chromosome | 19: 859453-867884 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Hydrolase, Protease, Serine protease |
| Biological process | Complement alternate pathway, Immunity, Innate immunity |
Function
Serine protease that initiates the alternative pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. In contrast to other complement pathways (classical, lectin and GZMK) that are directly activated by pathogens or antigen-antibody complexes, the alternative complement pathway is initiated by the spontaneous hydrolysis of complement C3. The alternative complement pathway acts as an amplification loop that enhances complement activation by mediating the formation of C3 and C5 convertases. Activated CFD cleaves factor B (CFB) when the latter is complexed with complement C3b, activating the C3 convertase of the alternative pathway.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.