A2M — Alpha-2-macroglobulin
A2M belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
A2M's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Lipid Signaling migration & adhesion | ADGRG1, ARHGEF15, CNOT6L, CYYR1, DIP2B, HIP1R, PCDH1, PITPNC1 +3 more | View in SCUBA |
| Fibroblasts | Subepithelial Fibroblast Developmental | ABCA10, ABCA6, ABCA8, ABCA9, ADAMDEC1, CFD, CTSC, EDIL3 +8 more | View in SCUBA |
| Glial cells | BMP-SMAD Signaling Neroprotection | AQP1, ARC, CAPS, CRLF1, GDNF, ID1, ID3, NRXN2 +3 more | View in SCUBA |
| Lymphatic endothelial | Lymphatic Valve Formation Valve formation | CD34, CISD1, FAM89A, FHL3, FSCN1, GJC2, GRAP, HTRA1 +5 more | View in SCUBA |
| Macrophages | Endosomal Membrane Trafficking Vesicular traficking | AP1B1, ARHGAP4, ARHGEF6, ATG4C, B3GNT7, CRTAP, ETV5, FYB1 +20 more | View in SCUBA |
| Pericytes | ER-Actin Cytoskeletal Cytoskeletal | CSDE1, GTF2I, IQGAP1, KTN1, MAP4K4, SEC62, SERINC1, WASF2 | View in SCUBA |
About the gene
| Synonyms | CPAMD5, FWP007, S863-7 |
|---|---|
| Chromosome | 12: 9067664-9116229 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Candidate cardiovascular disease genes, Plasma proteins, Predicted secreted proteins |
| Molecular function | Protease inhibitor, Serine protease inhibitor |
Function
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.