Subepithelial Fibroblast
Gene co-expression module in Fibroblasts
| Category | Developmental |
|---|---|
| Genes | 17 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes HAPLN1 (hyaluronan and proteoglycan link protein, ECM), ADAMDEC1 (ADAM metalloprotease decysin, expressed in stromal fibroblasts), ABCA8/ABCA9/ABCA10/ABCA6 (ABC transporters, lipid transport, expressed in fibroblasts), TCF21 (transcription factor marking subepithelial fibroblasts/telocytes), EDIL3 (EGF-like domain ECM protein), SCARA5 (scavenger receptor), EPHA7 (ephrin receptor), SPRY1 (Sprouty, RTK signaling inhibitor), CFD (complement factor D, adipose/stromal), LTBP4 (latent TGF-beta binding protein), A2M (alpha-2-macroglobulin), and CTSC (cathepsin C) define a specialized subepithelial/telocyte fibroblast identity. TCF21 is a canonical marker of intestinal subepithelial myofibroblasts/telocytes. HAPLN1 marks a specific stromal fibroblast subset in the intestine. This module is significantly downregulated in both UC and CD inflammation and recovers in remission, consistent with a homeostatic specialized fibroblast state. Neighbor to M65 and M4.
Genes
A2M, ABCA10, ABCA6, ABCA8, ABCA9, ADAMDEC1, CFD, CTSC, EDIL3, EPHA7, FZD1, HAPLN1, LTBP4, MCTP1, SCARA5, SPRY1, TCF21
Most correlated modules
- Stromal Niche Signaling · correlation 0.91
- Microfibril ECM Fibroblast · correlation 0.79
- Homeostatic Fibroblast State · correlation 0.79
- Homeostatic Fibroblast Identity · correlation 0.76
- Elastic Fiber ECM · correlation 0.74
- Quiescent Stromal Identity · correlation 0.73
- OSR1+ Deep Fibroblast · correlation 0.70
- CCL11 Secretory Fibroblast · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.