ABCA8 — ATP binding cassette subfamily A member 8
ABCA8 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ABCA8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Subepithelial Fibroblast Developmental | A2M, ABCA10, ABCA6, ABCA9, ADAMDEC1, CFD, CTSC, EDIL3 +8 more | View in SCUBA |
| Glial cells | Peripheral Nerve Myelination Myelination | AKAP12, CIT, COL27A1, ITGB4, LGI4, NRP2, SAMHD1, SYT10 | View in SCUBA |
| Pericytes | Stromal ECM Production ECM production | CCL11, CFD, CTSK, DCN, FBLN1, LUM, MFAP4, VCAN | View in SCUBA |
About the gene
| Synonyms | KIAA0822 |
|---|---|
| Chromosome | 17: 68867289-68955392 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted membrane proteins, Transporters |
| Molecular function | Translocase |
| Biological process | Lipid transport, Transport |
Function
Catalyzes ATP-dependent import of organic anions such as taurocholate and estrone sulfate. In vitro, also imports ochratoxin A. Also mediates cholesterol efflux independent of apolipoprotein, and plays a role in sphingomyelin production in oligodendrocytes. Catalyzes ATP-dependent efflux of cholesterol and taurocholate. Interaction with ABCA1 potentiates cholesterol efflux to lipid-free APOA1, which regulates high-density lipoprotein cholesterol levels
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.