EZH1 — Enhancer of zeste 1 polycomb repressive complex 2 subunit
EZH1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EZH1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | T Cell Maturation T cell maturation | CDK13, CWF19L2, EMB, ICE1, IKZF1, JAK1, KLF13, NUB1 +16 more |
About the gene
| Synonyms | KIAA0388, KMT6B |
|---|---|
| Chromosome | 17: 42700275-42745049 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Chromatin regulator, Methyltransferase, Repressor, Transferase |
| Biological process | Transcription, Transcription regulation |
Function
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.