CDK13 — Cyclin dependent kinase 13
CDK13 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CDK13's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B-cell signaling regulators B cell maturation | ACAP2, BCL2L11, EHMT1, FNBP1, ITSN2, JAK1, KMT2A, ST6GAL1 +3 more | View in SCUBA |
| CD4⁺ T cells | Transcription/RNA processing RNA processing | ANKRD17, BDP1, CCDC97, CHIC2, CLK4, CNOT6L, CRNKL1, ELF1 +29 more | View in SCUBA |
| Gamma-delta T cells | T Cell Maturation T cell maturation | CWF19L2, EMB, EZH1, ICE1, IKZF1, JAK1, KLF13, NUB1 +16 more | |
| Innate lymphoid cells | Cytoskeletal Remodeling Cytoskeleton & motility | BCLAF1, BPTF, CBL, IQGAP2, KDM2A, KDM5A, LTC4S, MACF1 +8 more | View in SCUBA |
| Macrophages | Transcriptional Repression Housekeeping | AKAP8, ANKRD11, ARIH2, BACH1, CCNT2, CEP95, CSNK1D, FNBP4 +23 more | View in SCUBA |
About the gene
| Synonyms | CDC2L, CDC2L5, CHED, KIAA1791 |
|---|---|
| Chromosome | 7: 39950121-40099580 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
| Biological process | Host-virus interaction, mRNA processing, mRNA splicing |
Function
Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.