T Cell Maturation
Gene co-expression module in Gamma-delta T cells
| Category | T cell maturation |
|---|---|
| Genes | 25 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 25 genes have a known function matching the annotation |
Why this annotation
Hub genes include IKZF1 (Ikaros, master T cell development/maturation transcription factor), KLF13 (T cell TF regulating IL-2, CD95), STK4 (MST1 kinase, critical for T cell survival and maturation), CDK13 (transcription-coupled kinase), UBE3A (E3 ubiquitin ligase regulating TCR signaling), and EZH1 (PRC2 methyltransferase, lymphocyte development). IKZF1 and KLF13 are hallmarks of T cell maturation programs. STK4/MST1 is essential for naive T cell egress and survival. TRIM33 and UBN1 add ubiquitin/chromatin regulatory context consistent with lymphocyte maturation. The module reflects a T cell maturation and survival transcriptional program.
Genes
CDK13, CWF19L2, EMB, EZH1, ICE1, IKZF1, JAK1, KLF13, NUB1, PICALM, PPM1A, PPP3R1, PTPRA, RAB14, RBM5, SCAF4, SP100, STK4, TRIM33, UBE3A, UBN1, USP8, VPS26B, ZNF800, ZNF83
Most correlated modules
- Chromatin Epigenetic Regulation · correlation 0.84
- Centrosome Organization · correlation 0.83
- mRNA Splicing Processing · correlation 0.83
- Osmotic Stress Response · correlation 0.82
- T Cell Migration · correlation 0.80
- Histone Demethylase Program · correlation 0.79
- RNA Splicing Processing · correlation 0.78
- RNA Surveillance/NMD · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.