SCUBA

EMB — Embigin

EMB belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

EMB's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsLeukocyte Migration Signaling
migration & adhesion
AP1S3, ARID5B, ATP2B1, CYBB, DOCK8, GLIPR1, IQGAP1, KDM2A +5 moreView in SCUBA
CD4⁺ T cellsT cell co-receptors
T cell development
AGO4, ARRB2, CAPG, CD200R1, CD40LG, CD96, FKBP11, GAB3 +13 moreView in SCUBA
CD8⁺ T cellsActomyosin Motility
Cytoskeletal
ACTR2, ADGRE5, AP2B1, ARGLU1, CAPNS1, GNAI2, MYH9, PPP1R12A +2 moreView in SCUBA
EnterocytesMature colonocyte brush-border
Epithelial development
AGMO, ATP8A1, CA3, CNKSR3, COBL, EPB41L3, NGEF, PAG1 +2 moreView in SCUBA
Gamma-delta T cellsT Cell Maturation
T cell maturation
CDK13, CWF19L2, EZH1, ICE1, IKZF1, JAK1, KLF13, NUB1 +16 more
Innate lymphoid cellsNK Cytotoxic Regulation
Cytotoxicity
ARHGAP30, BIN2, CAPN12, CHD9, CLK1, CTSC, CYB5B, DDX27 +29 moreView in SCUBA
MacrophagesResident Mac Identity
Tissue homeostasis
ACVRL1, CCND1, CD200R1, CFD, CR1, CTSF, EPHX1, F13A1 +16 moreView in SCUBA
MonocytesClassical Monocyte Trafficking
Migration & adhesion
ANXA6, CKAP4, F5, GCA, MAP2K6, MPP7, MSRB1, PADI4 +4 moreView in SCUBA
Mucosal-associated invariant T cellT cell Transcriptional Identity
T cell maturation
AAK1, ANKRD36B, ATG16L2, BCL11B, ETS1, GOLGA8B, HNRNPUL2, LSM14A +8 more
NeutrophilsmRNA Splicing Processing
Housekeeping
ABCA13, ATP2A3, FBXO9, LUC7L3, NKTR, OGT, PAXBP1, PNN +8 more

About the gene

SynonymsMGC71745
Chromosome5: 50396192-50443248
Predicted locationMembrane
Essential geneNo
Protein classPredicted membrane proteins, Transporters

Function

Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1, SLC16A6 and SLC16A7 to the cell membrane (By similarity)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.