IKZF1 — IKAROS family zinc finger 1
IKZF1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IKZF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Lymphoid signaling regulators BCR/AP1/NFKb pathway | CCDC88B, FGD2, LENG8, MACF1, OGT, PCSK7, PHYKPL, PNISR +4 more | View in SCUBA |
| Gamma-delta T cells | T Cell Maturation T cell maturation | CDK13, CWF19L2, EMB, EZH1, ICE1, JAK1, KLF13, NUB1 +16 more | |
| Innate lymphoid cells | Inflammasome Activation Inflammation | ANKRD28, AP3D1, ARHGEF7, CCNH, CD55, CDC42SE1, CHD7, CHKA +19 more | View in SCUBA |
| Macrophages | Myeloid Differentiation Identity Developmental | ADCK2, ALOX5, ATP2C1, CCDC6, CDK6, CMTM7, DEF6, EEF2K +21 more | View in SCUBA |
| Mucosal-associated invariant T cell | STAT4 T cell Identity T cell maturation | ATF7IP, CAMK4, CBLB, CD96, CELF2, DENND4A, JMJD1C, PIP4K2A +7 more | |
| Neutrophils | Apoptotic Neutrophil Program Developmental | ANO10, APAF1, ARFGEF1, ATF7IP, BLTP1, CEP350, FAR2, FBXW2 +5 more |
About the gene
| Synonyms | hIk-1, Hs.54452, IKAROS, LyF-1, PPP1R92, ZNFN1A1 |
|---|---|
| Chromosome | 7: 50304068-50405101 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors |
| Molecular function | Activator, Chromatin regulator, Developmental protein, DNA-binding, Repressor |
| Biological process | Cell cycle, Transcription, Transcription regulation |
Function
Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.