FABP6 — Fatty acid binding protein 6
FABP6 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FABP6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Mixed Metabolic Ambient Technical artifact | DPYD, ENO2, FCGRT, GRAP, SMURF2, SPINK2, SYNJ2BP, TNFRSF10B +1 more | View in SCUBA |
| Enterocytes | Lipid/bile acid uptake Absorption | AKR1B10, DHRS11, FABP1, GLRX, NAALADL1, PHGR1, RBP2, SLC25A5 +2 more | View in SCUBA |
About the gene
| Synonyms | I-15P, I-BABP, I-BALB, I-BAP, ILBP, ILBP3, ILLBP |
|---|---|
| Chromosome | 5: 160187367-160238735 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted intracellular proteins |
| Biological process | Lipid transport, Transport |
Function
Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). In vitro binds to bile acids in the order: deoxycholic acid > cholic acid > chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated > glycine-conjugated > unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion (By similarity). Essential for the survival of colon cancer cells to bile acid-induced apoptosis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.