DHRS11 — Dehydrogenase/reductase 11
DHRS11 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DHRS11's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Lipid/bile acid uptake Absorption | AKR1B10, FABP1, FABP6, GLRX, NAALADL1, PHGR1, RBP2, SLC25A5 +2 more | View in SCUBA |
| Hematopoietic progenitor cells | Erythroid Differentiation Erythropoietic | DNAJC6, EPOR, FHL2, GATA1, HBD, KLF1, LXN, MICAL2 +5 more |
About the gene
| Synonyms | MGC4172, SDR24C1 |
|---|---|
| Chromosome | 17: 36591879-36600804 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Oxidoreductase |
| Biological process | Lipid metabolism, Steroid metabolism |
Function
Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta- hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.