GLRX — Glutaredoxin
GLRX belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GLRX's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Activated Treg Immune regulation | ACOT9, AHSP, AKIP1, BASP1, CASP1, CCR8, CD177, CSF2RB +13 more | View in SCUBA |
| Enterocytes | Lipid/bile acid uptake Absorption | AKR1B10, DHRS11, FABP1, FABP6, NAALADL1, PHGR1, RBP2, SLC25A5 +2 more | View in SCUBA |
| Gamma-delta T cells | Effector Cell Migration migration & adhesion | ADAM15, ADAM8, ANXA2, APOBEC3G, CD52, CTSC, DSTN, FUT11 +17 more | |
| Mucosal-associated invariant T cell | Oxidative Stress Response Stress | CDC42EP3, CTU1, EXOSC5, GNPDA1, HTATIP2, KRCC1, MLX, MRPS6 +11 more |
About the gene
| Synonyms | GRX, GRX1 |
|---|---|
| Chromosome | 5: 95751319-95822726 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Biological process | Electron transport, Transport |
Function
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.