FZD5 — Frizzled class receptor 5
FZD5 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FZD5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Lipid Metabolism Nutrient processing | ABCD1, ACOT11, ACSS2, ADAP1, AP1B1, ATP1A1, CACFD1, CAPN5 +29 more | View in SCUBA |
About the gene
| Synonyms | C2orf31, DKFZP434E2135, HFZ5 |
|---|---|
| Chromosome | 2: 207762598-207769906 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | G-protein coupled receptors, Predicted membrane proteins |
| Molecular function | Developmental protein, G-protein coupled receptor, Receptor, Transducer |
| Biological process | Wnt signaling pathway |
Function
Receptor for Wnt proteins. Functions in the canonical Wnt/beta- catenin signaling pathway. In vitro activates WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 signaling (By similarity). In neurons, activation by WNT7A promotes formation of synapses. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity). Plays a role in ocular development.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.